Tumour-derived exosomes as a signature of pancreatic cancer - liquid biopsies as indicators of tumour progression

• Published in: Oncotarget Vol. 8; no. 10; pp. 17279 - 17291
• Main Authors: Nuzhat, Zarin, Kinhal, Vyjayanthi, Sharma, Shayna, Rice, Gregory E, Joshi, Virendra, Salomon, Carlos
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 07.03.2017
• Subjects: Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Biopsy; Cell-Derived Microparticles - genetics; Cell-Derived Microparticles - metabolism; Disease Progression; Exosomes - genetics; Exosomes - metabolism; Humans; MicroRNAs - genetics; MicroRNAs - metabolism; Pancreas - metabolism; Pancreas - pathology; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Review; Sensitivity and Specificity; pancreatic cancer; biomarkers; exosomes

Pancreatic cancer is the fourth most common cause of death due to cancer in the world. It is known to have a poor prognosis, mostly because early stages of the disease are generally asymptomatic. Progress in pancreatic cancer research has been slow, leaving several fundamental questions pertaining t...