Dimeric camptothecin-loaded mPEG-PCL nanoparticles with high drug loading and reduction-responsive drug release

• Published in: Colloid and polymer science Vol. 298; no. 1; pp. 51 - 58
• Main Authors: Chi, Yanwei, Wang, Zhiying, Wang, Jie, Dong, Wenpei, Xin, Pengyang, Bi, Jingjing, Jiang, Tao, Chen, Chang-Po
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2020; Springer Nature B.V
• Subjects: Biocompatibility; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Dimers; Drug delivery systems; Food Science; Micelles; MPEG encoders; Nanoparticles; Nanotechnology and Microengineering; Original Contribution; Physical Chemistry; Polyethylene glycol; Polymer Sciences; Reduction; Soft and Granular Matter; Toxicity; Reduction-responsive; Camptothecin; Dimer; Drug delivery; mPEG-PCL

Camptothecin (CPT) is a potent and broad-spectrum anti-tumor drug, but its clinical application is limited due to its poor water solubility, toxicity, and low drug-loading potential. Different delivery protocols have been developed to optimize the therapeutic effects of CPT. In this study, CPT was m...