Functional MIF promoter haplotypes modulate Th17-related cytokine expression in peripheral blood mononuclear cells from control subjects and rheumatoid arthritis patients

• Published in: Cytokine (Philadelphia, Pa.) Vol. 115; pp. 89 - 96
• Main Authors: Hernández-Palma, Luis Alexis, García-Arellano, Samuel, Bucala, Richard, Llamas-Covarrubias, Mara Anaís, De la Cruz-Mosso, Ulises, Oregon-Romero, Edith, Cerpa-Cruz, Sergio, Parra-Rojas, Isela, Plascencia-Hernández, Arturo, Muñoz-Valle, José Francisco
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2019
• Subjects: Adult; Arthritis, Rheumatoid - genetics; Cytokines - genetics; Female; Haplotypes; Haplotypes - genetics; Humans; Intramolecular Oxidoreductases - genetics; Leukocytes, Mononuclear - metabolism; Lipopolysaccharide; Macrophage Migration-Inhibitory Factors - genetics; Male; Middle Aged; MIF; Polymorphism, Genetic - genetics; Promoter Regions, Genetic - genetics; Rheumatoid arthritis; Th17 Cells - metabolism; Th17 profile cytokines; Haplotypes; Lipopolysaccharide; MIF; Th17 profile cytokines; Rheumatoid arthritis

•MIF and LPS induce the Th17 cytokine secretion profile in PBMC from RA patients.•In a Mexican-Mestizo population, the most frequent MIF haplotypes were 5G, 6G, and 7C.•MIF haplotypes modulate the secretion of cytokines related to the Th17 profile in PBMC cultures. Rheumatoid arthritis (RA) is a chr...