Antibiotic-loaded acrylic bone cements: An in vitro study on the release mechanism and its efficacy

• Published in: Materials Science & Engineering C Vol. 33; no. 5; pp. 3025 - 3032
• Main Authors: Miola, Marta, Bistolfi, Alessandro, Valsania, Maria Carmen, Bianco, Carlotta, Fucale, Giacomo, Verné, Enrica
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2013
• Subjects: Acrylates; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacology; Antibacterial; Antibiotics; Bone Cements; Gentamicins - administration & dosage; In Vitro Techniques; Microscopy, Electron, Scanning; Release; Antibacterial; Bone cements; Antibiotics; Release

An in vitro study was carried out in order to investigate the antibiotic release mechanism and the antibacterial properties of commercially (Palacos® R+G and Palacos® LV+G) and manually (Palacos® R+GM and Palacos® LV+GM) blended gentamicin-loaded bone cements. Samples were characterized by means of...