Comprehensive analysis of the potential mechanism of gansui in blocking non-small cell lung cancer progression

• Published in: Pharmaceutical biology Vol. 63; no. 1; pp. 170 - 187
• Main Authors: Yang, Xiaoxu, Li, Wenlan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 25.02.2025; Taylor & Francis Group
• Subjects: A549 Cells; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Apoptosis - drug effects; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Disease Progression; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; Gansui; Humans; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - pathology; molecular docking; Molecular Docking Simulation; network pharmacology; Non-small cell lung cancer; Paclitaxel - pharmacology; Protein Interaction Maps - drug effects; Gansui; molecular docking; network pharmacology; Non-small cell lung cancer

Gansui [ T. N. Liou ex S.B.Ho (Euphorbiaceae)] has been reported to inhibit the proliferation of non-small cell lung cancer (NSCLC) cells; however, its underlying pharmacological mechanism remains unclear. To investigate the potential effects and mechanisms of Gansui in blocking NSCLC progression. T...