StarD13 3’-untranslated region functions as a ceRNA for TP53INP1 in prohibiting migration and invasion of breast cancer cells by regulating miR-125b activity

• Published in: European journal of cell biology Vol. 97; no. 1; pp. 23 - 31
• Main Authors: Zheng, Lufeng, Li, Xiaoman, Chou, Jinjiang, Xiang, Chenxi, Guo, Qianqian, Zhang, Zhiting, Guo, Xinwei, Gao, Lanlan, Xing, Yingying, Xi, Tao
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.01.2018
• Subjects: 3' Untranslated Regions; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Proliferation; ceRNA; Female; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins - genetics; Heat-Shock Proteins - metabolism; Humans; Invasion; MicroRNAs - genetics; Migration; Neoplasm Invasiveness; StarD13; TP53INP1; Tumor Cells, Cultured; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Wound Healing; MMP; SPARC; Migration; StarD13; TP53INP1; MiRNA; AGO2; MREs; RIP; 3’UTR; CeRNA; Invasion; ceRNA

Competitive endogenous messenger RNA (ceRNA) affects transcription of other RNA molecules by competitively binding common microRNAs. Previous studies have shown that TP53INP1 functions as a suppressor in tumor metastasis. Our study elucidated StarD13 messenger RNA as a ceRNA in regulating migration...