No Pattern Separation in the Human Hippocampus

• Published in: Trends in cognitive sciences Vol. 24; no. 12; pp. 994 - 1007
• Main Author: Quian Quiroga, Rodrigo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2020
• Subjects: Concept Cells; conjunctive coding; engram; episodic memory; Hippocampus - physiology; human intelligence; Humans; Memory, Episodic; neural coding; Neurons - physiology; episodic memory; human intelligence; engram; conjunctive coding; Concept Cells; neural coding

Pattern separation is a basic principle of neuronal coding that precludes memory interference in the hippocampus. Its existence is supported by numerous theoretical, computational, and experimental findings in different species. However, I argue that recent evidence from single-neuron recordings sug...