The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA

• Published in: Clinical cancer research Vol. 24; no. 23; pp. 6053 - 6065
• Main Authors: Gu, Long, Lingeman, Robert, Yakushijin, Fumiko, Sun, Emily, Cui, Qi, Chao, Jianfei, Hu, Weidong, Li, Hongzhi, Hickey, Robert J., Stark, Jeremy M., Yuan, Yate-Ching, Chen, Yuan, Vonderfecht, Steven L., Synold, Timothy W., Shi, Yanhong, Reckamp, Karen L., Horne, David, Malkas, Linda H.
• Format: Journal Article
• Language: English
• Published: United States 01.12.2018

Proliferating cell nuclear antigen (PCNA) plays an essential role in regulating DNA synthesis and repair and is indispensable to cancer cell growth and survival. We previously reported a novel cancer associated PCNA isoform (dubbed caPCNA), which was ubiquitously expressed in a broad range of cancer...