Formulation and Processing Strategies which Underpin Susceptibility to Matrix Crystallization in Amorphous Solid Dispersions

• Published in: Journal of pharmaceutical sciences Vol. 112; no. 1; pp. 108 - 122
• Main Authors: Moseson, Dana E., Hiew, Tze Ning, Su, Yongchao, Taylor, Lynne S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2023
• Subjects: Amorphous solid dispersion; Congruent release; Crystallization; Dissolution; Drug Liberation; Matrix crystallization; Polymers - chemistry; Sodium Dodecyl Sulfate - chemistry; Solubility; Supersaturation; Surface-Active Agents; Amorphous solid dispersion; Supersaturation; Congruent release; Matrix crystallization; Dissolution

Through matrix crystallization, an amorphous solid may transform directly into its more stable crystalline state, reducing the driving force for dissolution. Herein, the mechanism of matrix crystallization in an amorphous solid dispersion (ASD) was probed. ASDs of bicalutamide/copovidone were prepar...