Genes enriched in A/T-ending codons are co-regulated and conserved across mammals

• Published in: Cell systems Vol. 14; no. 4; pp. 312 - 323.e3
• Main Authors: Benisty, Hannah, Hernandez-Alias, Xavier, Weber, Marc, Anglada-Girotto, Miquel, Mantica, Federica, Radusky, Leandro, Senger, Gökçe, Calvet, Ferriol, Weghorn, Donate, Irimia, Manuel, Schaefer, Martin H., Serrano, Luis
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.04.2023
• Subjects: A/T-ending codons; Animals; co-regulation; Codon - genetics; Codon Usage; conservation; development; mammals; Mammals - genetics; RAS genes; RNA, Transfer - genetics; synonymous codons; translation efficiency; tRNA; Vertebrates - genetics; RAS genes; conservation; development; mammals; tRNA; synonymous codons; translation efficiency; A/T-ending codons; codon usage; co-regulation

Codon usage influences gene expression distinctly depending on the cell context. Yet, the importance of codon bias in the simultaneous turnover of specific groups of protein-coding genes remains to be investigated. Here, we find that genes enriched in A/T-ending codons are expressed more coordinatel...