The potential of chiroptical and vibrational spectroscopy of blood plasma for the discrimination between colon cancer patients and the control group

Colorectal cancer is one of the most abundant causes of cancer deaths in the world. At an early stage, the established clinical procedures have low reliability and sensitivity. Therefore, we tested a novel approach based on chiroptical methods such as electronic circular dichroism (ECD) and Raman op...

Full description

Saved in:
Bibliographic Details
Published inAnalyst (London) Vol. 140; no. 7; pp. 2287 - 2293
Main Authors Tatarkovič, Michal, Miškovičová, Michaela, Šťovíčková, Lucie, Synytsya, Alla, Petruželka, Luboš, Setnička, Vladimír
Format Journal Article
LanguageEnglish
Published England 07.04.2015
Subjects
Adult
Aged
Aged, 80 and over
Blood plasma
Cancer
Case-Control Studies
Circular Dichroism
Colon
Colonic Neoplasms - blood
Colonic Neoplasms - diagnosis
Discriminant analysis
Discrimination
Electronics
Female
Humans
Male
Middle Aged
Optical activity
Spectroscopy
Spectrum Analysis, Raman
Three dimensional
Online AccessGet full text

Cover

Abstract Colorectal cancer is one of the most abundant causes of cancer deaths in the world. At an early stage, the established clinical procedures have low reliability and sensitivity. Therefore, we tested a novel approach based on chiroptical methods such as electronic circular dichroism (ECD) and Raman optical activity (ROA). These methods are suitable for detecting slight changes in the 3D structure of chiral biomolecules, some of which may be caused by pathological processes occurring during cancer growth. Fifty-five blood plasma samples were analyzed using the combination of ECD and ROA supplemented by conventional Raman and FT-IR spectroscopy. All obtained spectra were evaluated together by linear discriminant analysis. The accuracy of sample discrimination reached 100% and the subsequent leave-one-out cross-validation resulted in 93% sensitivity and 81% specificity. The achieved results indicate that chiroptical methods supplemented by Raman and FT-IR spectroscopy might be new supporting and minimally invasive tools in the clinical diagnosis of colon cancer.
AbstractList Colorectal cancer is one of the most abundant causes of cancer deaths in the world. At an early stage, the established clinical procedures have low reliability and sensitivity. Therefore, we tested a novel approach based on chiroptical methods such as electronic circular dichroism (ECD) and Raman optical activity (ROA). These methods are suitable for detecting slight changes in the 3D structure of chiral biomolecules, some of which may be caused by pathological processes occurring during cancer growth. Fifty-five blood plasma samples were analyzed using the combination of ECD and ROA supplemented by conventional Raman and FT-IR spectroscopy. All obtained spectra were evaluated together by linear discriminant analysis. The accuracy of sample discrimination reached 100% and the subsequent leave-one-out cross-validation resulted in 93% sensitivity and 81% specificity. The achieved results indicate that chiroptical methods supplemented by Raman and FT-IR spectroscopy might be new supporting and minimally invasive tools in the clinical diagnosis of colon cancer.
Author Tatarkovič, Michal
Petruželka, Luboš
Šťovíčková, Lucie
Miškovičová, Michaela
Setnička, Vladimír
Synytsya, Alla
Author_xml – sequence: 1
  givenname: Michal
  surname: Tatarkovič
  fullname: Tatarkovič, Michal
  email: michal.tatarkovic@vscht.cz
  organization: Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic. michal.tatarkovic@vscht.cz
– sequence: 2
  givenname: Michaela
  surname: Miškovičová
  fullname: Miškovičová, Michaela
– sequence: 3
  givenname: Lucie
  surname: Šťovíčková
  fullname: Šťovíčková, Lucie
– sequence: 4
  givenname: Alla
  surname: Synytsya
  fullname: Synytsya, Alla
– sequence: 5
  givenname: Luboš
  surname: Petruželka
  fullname: Petruželka, Luboš
– sequence: 6
  givenname: Vladimír
  surname: Setnička
  fullname: Setnička, Vladimír
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25723848$$D View this record in MEDLINE/PubMed
BookMark eNqNkctOHDEQRa0IBMNjkw-IvIyQGsrP7l6iUXgJwQbWLbe7OjTqsR3bQ8R_8MF4BpI1q9JVnbpVqntAdpx3SMh3BqcMRHtmpXHAmgaev5EFE1pWSvFmhywAQFRcK7lPDlJ6LpKBgj2yz1XNRSObBXl7eEIafEaXJzNTP1L7NEUf8mSLNG6gL1MfTZ68KzoFtDn6ZH143bD97P1Aw2zSytDRR5qL2zAlG6fV5LZTtMf8F9FR6-eirHEWIw2lV1am7YbNkPWuGM_0d_TrcER2RzMnPP6sh-Tx4tfD8qq6vb-8Xp7fVlYonSstJeAoTY8GeN22XFuthqFnPeO10MAFmJGZpm0kt7K3wtRoONNcNUqMHMQh-fnhG6L_s8aUu1W5HefZOPTr1DFdF9uag_4CqiUHJXlb0JMP1JZPpYhjF8o7THztGHSbwLqlPL_bBnZT4B-fvut-hcN_9F9C4h0h-pS8
CitedBy_id crossref_primary_10_1016_j_aohep_2024_101519
crossref_primary_10_1016_j_clinbiochem_2019_04_004
crossref_primary_10_1016_j_saa_2023_123430
crossref_primary_10_1039_C6AN01247G
crossref_primary_10_1002_chir_22834
crossref_primary_10_1002_chir_22832
crossref_primary_10_3390_ph14090877
crossref_primary_10_1016_j_saa_2023_123392
crossref_primary_10_3390_s17122739
crossref_primary_10_1039_D0RA01384F
crossref_primary_10_31482_mmsl_2022_046
crossref_primary_10_1002_anie_202107600
crossref_primary_10_1002_ange_202107600
crossref_primary_10_1016_j_saa_2018_04_002
crossref_primary_10_3390_diagnostics11112048
crossref_primary_10_1002_jbio_202100195
crossref_primary_10_1016_j_saa_2019_04_067
crossref_primary_10_1080_10408347_2022_2036941
Cites_doi 10.1002/jrs.1747
10.1002/lapl.200710004
10.1007/s00216-013-6946-6
10.1039/c3an00370a
10.1002/9781118120392
10.1007/s00216-014-8358-7
10.1007/s00384-010-1027-1
10.1002/chir.22063
10.1002/chir.20803
10.1016/j.bbapap.2005.06.005
10.1007/s00214-011-1063-0
10.1021/ac901389p
10.1021/jp405981h
10.1038/srep04751
10.1039/b822354h
10.1182/blood-2012-02-413609
10.1016/S0169-7439(99)00047-7
10.1046/j.1523-1747.2000.00060.x
10.1366/0003702934067072
10.2174/1573411052948424
10.1093/jn/119.1.101
10.1016/S0079-6107(99)00017-6
10.1364/OE.19.013565
10.1039/C4AN01874E
10.1021/ac101334h
10.1039/b304992b
10.1002/jrs.4581
10.1039/C4RA10416A
10.1186/1476-4598-10-101
10.1016/j.saa.2013.11.031
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
7SR
7U5
8BQ
8FD
JG9
L7M
DOI 10.1039/c4an01880j
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
Engineered Materials Abstracts
Solid State and Superconductivity Abstracts
METADEX
Technology Research Database
Materials Research Database
Advanced Technologies Database with Aerospace
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
Materials Research Database
Engineered Materials Abstracts
Solid State and Superconductivity Abstracts
Technology Research Database
Advanced Technologies Database with Aerospace
METADEX
DatabaseTitleList MEDLINE
CrossRef
MEDLINE - Academic
Materials Research Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1364-5528
EndPage 2293
ExternalDocumentID 10_1039_C4AN01880J
25723848
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-JG
-~X
.HR
0-7
0R~
23M
2WC
4.4
5RE
705
70~
7~J
AAEMU
AAIWI
AAJAE
AANOJ
AAWGC
AAXHV
AAXPP
ABASK
ABDVN
ABEMK
ABGFH
ABJNI
ABOCM
ABPDG
ABRYZ
ABXOH
ACGFS
ACIWK
ACLDK
ADMRA
ADSRN
AEFDR
AENEX
AENGV
AESAV
AETIL
AFLYV
AFOGI
AFVBQ
AGEGJ
AGRSR
AGSTE
AHGCF
ALMA_UNASSIGNED_HOLDINGS
ANBJS
ANUXI
APEMP
ASKNT
AUDPV
AZFZN
BLAPV
BSQNT
C6K
CGR
COF
CS3
CUY
CVF
EBS
ECGLT
ECM
EE0
EF-
EIF
EJD
F5P
GGIMP
GNO
H13
HZ~
H~N
IDZ
J3G
J3H
J3I
M4U
N9A
NPM
O9-
P2P
R7B
R7E
RAOCF
RCNCU
RIG
ROL
RPMJG
RRA
RRC
RSCEA
SKM
SKR
SKZ
SLC
SLF
TN5
UPT
VH6
WH7
~02
.GJ
0UZ
186
1TJ
3EH
3O-
53G
71~
AAMEH
AAYXX
ACHDF
ACMRT
AFFNX
AGKEF
AHGXI
AIDUJ
ANLMG
ASPBG
AVWKF
BBWZM
C1A
CAG
CITATION
EEHRC
IDY
KC5
L-8
LPU
MVM
NDZJH
R56
RCLXC
RNS
RRXOS
SC5
SLH
XOL
XXG
ZCG
ZKB
ZXP
7X8
7SR
7U5
8BQ
8FD
JG9
L7M
ID FETCH-LOGICAL-c356t-6440ef4abea0279926c65ddb1b127360230af1a89842c4bc3a7ea21625853f203
ISSN 0003-2654
IngestDate Fri Oct 25 04:23:16 EDT 2024
Fri Oct 25 06:40:50 EDT 2024
Fri Aug 23 00:42:35 EDT 2024
Sat Sep 28 08:05:19 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c356t-6440ef4abea0279926c65ddb1b127360230af1a89842c4bc3a7ea21625853f203
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://pubs.rsc.org/en/content/articlepdf/2015/an/c4an01880j
PMID 25723848
PQID 1664205429
PQPubID 23479
PageCount 7
ParticipantIDs proquest_miscellaneous_1677997206
proquest_miscellaneous_1664205429
crossref_primary_10_1039_C4AN01880J
pubmed_primary_25723848
PublicationCentury 2000
PublicationDate 2015-04-07
PublicationDateYYYYMMDD 2015-04-07
PublicationDate_xml – month: 04
  year: 2015
  text: 2015-04-07
  day: 07
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Analyst (London)
PublicationTitleAlternate Analyst
PublicationYear 2015
References Synytsya (C4AN01880J-(cit29)/*[position()=1]) 2014; 45
Darvin (C4AN01880J-(cit22)/*[position()=1]) 2007; 4
Dong (C4AN01880J-(cit4)/*[position()=1]) 2014; 122
Synytsya (C4AN01880J-(cit15)/*[position()=1]) 2013; 405
Ekelund (C4AN01880J-(cit3)/*[position()=1]) 2010; 25
Parchaňský (C4AN01880J-(cit13)/*[position()=1]) 2014; 4
Člupek (C4AN01880J-(cit19)/*[position()=1]) 2007; 38
Redd (C4AN01880J-(cit24)/*[position()=1]) 1993; 47
Schulte (C4AN01880J-(cit25)/*[position()=1]) 2009; 81
Tatarkovič (C4AN01880J-(cit9)/*[position()=1]) 2013; 42
Barron (C4AN01880J-(cit11)/*[position()=1]) 2000; 73
Feltl (C4AN01880J-(cit28)/*[position()=1]) 2005; 1
Mavarani (C4AN01880J-(cit5)/*[position()=1]) 2013; 138
Krafft (C4AN01880J-(cit6)/*[position()=1]) 2009; 134
Tatarkovič (C4AN01880J-(cit16)/*[position()=1]) 2012; 24
Kelly (C4AN01880J-(cit20)/*[position()=1]) 2005; 1751
Murray (C4AN01880J-(cit21)/*[position()=1]) 2003
Lin (C4AN01880J-(cit10)/*[position()=1]) 2014; 4
Stewart (C4AN01880J-(cit1)/*[position()=1]) 2014
Stone (C4AN01880J-(cit7)/*[position()=1]) 2004; 126
Hata (C4AN01880J-(cit23)/*[position()=1]) 2000; 115
Urbanová (C4AN01880J-(cit30)/*[position()=1]) 2009; 21
Kinalwa (C4AN01880J-(cit31)/*[position()=1]) 2010; 82
Ollberding (C4AN01880J-(cit26)/*[position()=1]) 2012; 119
Lin (C4AN01880J-(cit8)/*[position()=1]) 2011; 19
Weymuth (C4AN01880J-(cit32)/*[position()=1]) 2013; 117
Parker (C4AN01880J-(cit27)/*[position()=1]) 1989; 119
De Maesschalck (C4AN01880J-(cit33)/*[position()=1]) 2000; 50
Piva (C4AN01880J-(cit2)/*[position()=1]) 2011; 130
Tatarkovič (C4AN01880J-(cit17)/*[position()=1]) 2015; 407
Šťovíčková (C4AN01880J-(cit18)/*[position()=1]) 2015
Minde (C4AN01880J-(cit14)/*[position()=1]) 2011; 10
Berova (C4AN01880J-(cit12)/*[position()=1]) 2012
References_xml – volume: 38
  start-page: 1174
  year: 2007
  ident: C4AN01880J-(cit19)/*[position()=1]
  publication-title: J. Raman Spectrosc.
  doi: 10.1002/jrs.1747
  contributor:
    fullname: Člupek
– volume-title: World Cancer Report 2014
  year: 2014
  ident: C4AN01880J-(cit1)/*[position()=1]
  contributor:
    fullname: Stewart
– volume: 4
  start-page: 452
  year: 2007
  ident: C4AN01880J-(cit22)/*[position()=1]
  publication-title: Laser Phys. Lett.
  doi: 10.1002/lapl.200710004
  contributor:
    fullname: Darvin
– volume: 405
  start-page: 5441
  year: 2013
  ident: C4AN01880J-(cit15)/*[position()=1]
  publication-title: Anal. Bioanal. Chem.
  doi: 10.1007/s00216-013-6946-6
  contributor:
    fullname: Synytsya
– volume: 138
  start-page: 4035
  year: 2013
  ident: C4AN01880J-(cit5)/*[position()=1]
  publication-title: Analyst
  doi: 10.1039/c3an00370a
  contributor:
    fullname: Mavarani
– volume-title: Harper's Illustrated Biochemistry
  year: 2003
  ident: C4AN01880J-(cit21)/*[position()=1]
  contributor:
    fullname: Murray
– volume-title: Comprehensive Chiroptical Spectroscopy
  year: 2012
  ident: C4AN01880J-(cit12)/*[position()=1]
  doi: 10.1002/9781118120392
  contributor:
    fullname: Berova
– volume: 407
  start-page: 1335
  year: 2015
  ident: C4AN01880J-(cit17)/*[position()=1]
  publication-title: Anal. Bioanal. Chem.
  doi: 10.1007/s00216-014-8358-7
  contributor:
    fullname: Tatarkovič
– volume: 25
  start-page: 1269
  year: 2010
  ident: C4AN01880J-(cit3)/*[position()=1]
  publication-title: Int. J. Colorectal Dis.
  doi: 10.1007/s00384-010-1027-1
  contributor:
    fullname: Ekelund
– volume: 24
  start-page: 951
  year: 2012
  ident: C4AN01880J-(cit16)/*[position()=1]
  publication-title: Chirality
  doi: 10.1002/chir.22063
  contributor:
    fullname: Tatarkovič
– volume: 21
  start-page: E215
  year: 2009
  ident: C4AN01880J-(cit30)/*[position()=1]
  publication-title: Chirality
  doi: 10.1002/chir.20803
  contributor:
    fullname: Urbanová
– volume: 1751
  start-page: 119
  year: 2005
  ident: C4AN01880J-(cit20)/*[position()=1]
  publication-title: Biochim. Biophys. Acta, Proteins Proteomics
  doi: 10.1016/j.bbapap.2005.06.005
  contributor:
    fullname: Kelly
– volume: 130
  start-page: 1261
  year: 2011
  ident: C4AN01880J-(cit2)/*[position()=1]
  publication-title: Theor. Chem. Acc.
  doi: 10.1007/s00214-011-1063-0
  contributor:
    fullname: Piva
– volume: 81
  start-page: 8426
  year: 2009
  ident: C4AN01880J-(cit25)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac901389p
  contributor:
    fullname: Schulte
– volume: 117
  start-page: 11943
  year: 2013
  ident: C4AN01880J-(cit32)/*[position()=1]
  publication-title: J. Phys. Chem. B
  doi: 10.1021/jp405981h
  contributor:
    fullname: Weymuth
– volume: 4
  year: 2014
  ident: C4AN01880J-(cit10)/*[position()=1]
  publication-title: Sci. Rep.
  doi: 10.1038/srep04751
  contributor:
    fullname: Lin
– volume: 134
  start-page: 1046
  year: 2009
  ident: C4AN01880J-(cit6)/*[position()=1]
  publication-title: Analyst
  doi: 10.1039/b822354h
  contributor:
    fullname: Krafft
– volume: 119
  start-page: 5817
  year: 2012
  ident: C4AN01880J-(cit26)/*[position()=1]
  publication-title: Blood
  doi: 10.1182/blood-2012-02-413609
  contributor:
    fullname: Ollberding
– volume: 50
  start-page: 1
  year: 2000
  ident: C4AN01880J-(cit33)/*[position()=1]
  publication-title: Chemom. Intell. Lab. Syst.
  doi: 10.1016/S0169-7439(99)00047-7
  contributor:
    fullname: De Maesschalck
– volume: 115
  start-page: 441
  year: 2000
  ident: C4AN01880J-(cit23)/*[position()=1]
  publication-title: J. Invest. Dermatol.
  doi: 10.1046/j.1523-1747.2000.00060.x
  contributor:
    fullname: Hata
– volume: 47
  start-page: 787
  year: 1993
  ident: C4AN01880J-(cit24)/*[position()=1]
  publication-title: Appl. Spectrosc.
  doi: 10.1366/0003702934067072
  contributor:
    fullname: Redd
– volume: 1
  start-page: 93
  year: 2005
  ident: C4AN01880J-(cit28)/*[position()=1]
  publication-title: Curr. Anal. Chem.
  doi: 10.2174/1573411052948424
  contributor:
    fullname: Feltl
– volume: 119
  start-page: 101
  year: 1989
  ident: C4AN01880J-(cit27)/*[position()=1]
  publication-title: J. Nutr.
  doi: 10.1093/jn/119.1.101
  contributor:
    fullname: Parker
– volume: 73
  start-page: 1
  year: 2000
  ident: C4AN01880J-(cit11)/*[position()=1]
  publication-title: Prog. Biophys. Mol. Biol.
  doi: 10.1016/S0079-6107(99)00017-6
  contributor:
    fullname: Barron
– volume: 19
  start-page: 13565
  year: 2011
  ident: C4AN01880J-(cit8)/*[position()=1]
  publication-title: Opt. Express
  doi: 10.1364/OE.19.013565
  contributor:
    fullname: Lin
– year: 2015
  ident: C4AN01880J-(cit18)/*[position()=1]
  publication-title: Analyst
  doi: 10.1039/C4AN01874E
  contributor:
    fullname: Šťovíčková
– volume: 42
  start-page: S107
  year: 2013
  ident: C4AN01880J-(cit9)/*[position()=1]
  publication-title: Eur. Biophys. J.
  contributor:
    fullname: Tatarkovič
– volume: 82
  start-page: 6347
  year: 2010
  ident: C4AN01880J-(cit31)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac101334h
  contributor:
    fullname: Kinalwa
– volume: 126
  start-page: 141
  year: 2004
  ident: C4AN01880J-(cit7)/*[position()=1]
  publication-title: Faraday Discuss.
  doi: 10.1039/b304992b
  contributor:
    fullname: Stone
– volume: 45
  start-page: 903
  year: 2014
  ident: C4AN01880J-(cit29)/*[position()=1]
  publication-title: J. Raman Spectrosc.
  doi: 10.1002/jrs.4581
  contributor:
    fullname: Synytsya
– volume: 4
  start-page: 57125
  year: 2014
  ident: C4AN01880J-(cit13)/*[position()=1]
  publication-title: RSC Adv.
  doi: 10.1039/C4RA10416A
  contributor:
    fullname: Parchaňský
– volume: 10
  start-page: 101
  year: 2011
  ident: C4AN01880J-(cit14)/*[position()=1]
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-10-101
  contributor:
    fullname: Minde
– volume: 122
  start-page: 288
  year: 2014
  ident: C4AN01880J-(cit4)/*[position()=1]
  publication-title: Spectrochim. Acta, Part A
  doi: 10.1016/j.saa.2013.11.031
  contributor:
    fullname: Dong
SSID ssj0001050
Score 2.2810888
Snippet Colorectal cancer is one of the most abundant causes of cancer deaths in the world. At an early stage, the established clinical procedures have low reliability...
SourceID proquest
crossref
pubmed
SourceType Aggregation Database
Index Database
StartPage 2287
SubjectTerms Adult
Aged
Aged, 80 and over
Blood plasma
Cancer
Case-Control Studies
Circular Dichroism
Colon
Colonic Neoplasms - blood
Colonic Neoplasms - diagnosis
Discriminant analysis
Discrimination
Electronics
Female
Humans
Male
Middle Aged
Optical activity
Spectroscopy
Spectrum Analysis, Raman
Three dimensional
Title The potential of chiroptical and vibrational spectroscopy of blood plasma for the discrimination between colon cancer patients and the control group
URI https://www.ncbi.nlm.nih.gov/pubmed/25723848
https://search.proquest.com/docview/1664205429
https://search.proquest.com/docview/1677997206
Volume 140
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELbK7gEuiDflJSO4ZnFix2mOVdXVsirlsKnUW-SkDnQXkqpNVyq_gx_Bz2T8bCoeWrhEbRwnlefrPJxvZhB6OygpmB2eBiFPRcDimAaFlDSQ4FoPeFiSSieFfZjysxk7n8fzXu9Hh7W0bYuT8ttv80r-R6pwDuSqsmT_QbL-pnACPoN84QgShuONZbxqWkX4MT5l-Xm5blatrwBwrYJhu9uncypV7cpmpd-qa8q66iK9-So82VAl6ZpGXxoXjsWlSlvXiiBWyrUrxbrx5EtHd__k97F8dWZV8aTttg3x-w6ZaMX6qgFF5dn7e4ricqNHmmvRofZ7A3LRqsErOzrZlkuPzotdvWs3O7NZ_MVOsZsaYay5MMmBoqZBxE196RNpdDPlLIhjm0vulLcp9mRRmnRVcWQtubRfTSfGX0wGoariaslETVRtusu9YXRkgOnH_HQ2meTZeJ7dQscRqDTQpcfDcfZ-4q0--KnEdWdUP9yVwqXpu_29D52fP0Q02rPJ7qG7NiTBQ4Ov-6gn6wfo9sh1AnyIvgPOsMcZbircwRkGFOAOznAXZ-pajTNscIYBZxgggw9xhi3OsMYZNjjDDmf6CWqSxRnWOHuEZqfjbHQW2G4eQUlj3gbgeBNZMVFIQWAJ04iXPF4sirAIwYXmKhYWVSgG6YBFJStKKhIpohDic_Aoq4jQx-iobmr5FOEFB_USyZBANM7Afy9YRCSvGC1kUVWLpI_euGXOV6ZoS67JFjTNR2w41cI476PXTgI5LKh6USZq2Ww3ecghKieqk9vfrkkSlXROeB89MeLzzwIzCJ4wGzy7wezn6M7-D_ACHbXrrXwJfm5bvLIQ-wkE3rGr
link.rule.ids 315,783,787,27936,27937
linkProvider Royal Society of Chemistry
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+potential+of+chiroptical+and+vibrational+spectroscopy+of+blood+plasma+for+the+discrimination+between+colon+cancer+patients+and+the+control+group&rft.jtitle=Analyst+%28London%29&rft.au=Tatarkovic%2C+Michal&rft.au=Miskovicova%2C+Michaela&rft.au=Stovickova%2C+Lucie&rft.au=Synytsya%2C+Alla&rft.date=2015-04-07&rft.issn=0003-2654&rft.eissn=1364-5528&rft.volume=140&rft.issue=7&rft.spage=2287&rft.epage=2293&rft_id=info:doi/10.1039%2Fc4an01880j&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-2654&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-2654&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-2654&client=summon