Interleukin-15 in autoimmunity

• Published in: Cytokine (Philadelphia, Pa.) Vol. 136; p. 155258
• Main Authors: Allard-Chamard, Hugues, Mishra, Hemant K., Nandi, Madhuparna, Mayhue, Marian, Menendez, Alfredo, Ilangumaran, Subburaj, Ramanathan, Sheela
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2020
• Subjects: Autoimmunity; IL-15; Immunotherapy; Rheumatoid arthritis; Type 1 diabetes; Autoimmunity; sIL-15Rα:IL-15; T1D; Treg; LSP; mIL-15Rα; IL-15; IBD; SCID; RA; SSP; UTR; Tg; Type 1 diabetes; Rheumatoid arthritis; Immunotherapy; DC

•IL-15 in implicated in various autoimmune diseases.•IL-15 is a potential immunotherapeutic target in autoimmunity.•Biologics targeting IL-15 or its receptors are in clinical or pre-clinical stages. Interleukin-15 (IL-15) is a member of the IL-2 family of cytokines, which use receptor complexes cont...