Determination of cannabinoids in human cerumen samples by use of UPLC-MS/MS as a potential biomarker for drug use

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 231; p. 115412
• Main Authors: Christodoulou, M.C., Constantinou, M.S., Louppis, A.P., Christou, A., Stavrou, I.J., Kapnissi-Christodoulou, C.P.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 05.07.2023
• Subjects: ANOVA One-Way Factor Analysis; Biomarkers; Cannabinoids; Cannabinoids - analysis; Cannabinol - analysis; Cannabis; Cerumen; Cerumen - chemistry; Chromatography, Liquid - methods; Dronabinol - analysis; Female; Hallucinogens; Humans; Male; Substance-Related Disorders; Tandem Mass Spectrometry - methods; UPLC-MS/MS; Δ9-THC detection window; Cerumen; UPLC-MS/MS; Cannabinoids; ANOVA One-Way Factor Analysis; Δ9-THC detection window; Δ-THC detection window

A quantitative analytical procedure was developed and validated by the use of Ultra- Performance Liquid Chromatography tandem Mass Spectrometry (UPLC-MS/MS) for the determination of Cannabidiol (CBD), Cannabinol (CBN), Δ9-Tetrahydrocannabinol (Δ9-THC), Cannabichromene (CBC), Cannabigerol (CBG) and 1...