Exosomes derived from platelet-rich plasma mediate hyperglycemia-induced retinal endothelial injury via targeting the TLR4 signaling pathway

• Published in: Experimental eye research Vol. 189; p. 107813
• Main Authors: Zhang, Wei, Dong, Xue, Wang, Tian, Kong, Yichun
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2019
• Subjects: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy - genetics; Diabetic Retinopathy - metabolism; Diabetic Retinopathy - pathology; Endothelium, Vascular - metabolism; Endothelium, Vascular - ultrastructure; Exosomes; Exosomes - metabolism; Gene Expression Regulation; Humans; Hyperglycemia - metabolism; Hyperglycemia - pathology; Immunohistochemistry; Microscopy, Electron, Transmission; Platelet-Rich Plasma - metabolism; Platelets; Rats; Reactive oxygen species; Reactive Oxygen Species - metabolism; Retinal endothelial injury; Retinal Vessels - metabolism; Retinal Vessels - ultrastructure; Signal Transduction; TLR4; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - metabolism; Reactive oxygen species; Retinal endothelial injury; Exosomes; Platelets; TLR4

In this study, we aimed to investigate whether exosomes derived from platelet-rich plasma (PRP-Exos) can regulate hyperglycemia-induced retinal injury via targeting the TLR4 signaling pathway. We studied the effects of PRP-Exos on retinal endothelial injury in diabetic rats and human retinal endothe...