Vaginal semisolid products: Technological performance considering physiologic parameters

• Published in: European journal of pharmaceutical sciences Vol. 109; pp. 556 - 568
• Main Authors: Machado, Rita Monteiro, Palmeira-de-Oliveira, Ana, Martinez-de-Oliveira, José, Palmeira-de-Oliveira, Rita
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.11.2017
• Subjects: Adhesiveness; Administration, Intravaginal; Animals; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - chemistry; Drug Compounding; Female; Hormones - administration & dosage; Hormones - chemistry; Hydrogen-Ion Concentration; Osmolar Concentration; Physiologic methods; Semisolids; Swine; Vagina; Vaginal Creams, Foams, and Jellies - administration & dosage; Vaginal Creams, Foams, and Jellies - chemistry; Vaginal drug delivery; Vaginal products; Viscosity; Vaginal drug delivery; Semisolids; Physiologic methods; Vaginal products

Vaginal semisolid products are frequently used to treat vaginal infections and atrophy-related symptoms of menopause. Formulations composition and the methods for their characterization, especially those developed concerning the target epithelia, are key tools to predict in vivo results at early sta...