Lowered expression of microRNA-125a-5p in human hepatocellular carcinoma and up-regulation of its oncogenic targets sirtuin-7, matrix metalloproteinase-11, and c-Raf

• Published in: Oncotarget Vol. 8; no. 15; pp. 25289 - 25299
• Main Authors: Coppola, Nicola, de Stefano, Giorgio, Panella, Marta, Onorato, Lorenzo, Iodice, Valentina, Minichini, Carmine, Mosca, Nicola, Desiato, Luisa, Farella, Nunzia, Starace, Mario, Liorre, Giulia, Potenza, Nicoletta, Sagnelli, Evangelista, Russo, Aniello
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 11.04.2017
• Subjects: Aged; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Proliferation - physiology; Down-Regulation; Female; Humans; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Matrix Metalloproteinase 11 - genetics; Matrix Metalloproteinase 11 - metabolism; MicroRNAs - biosynthesis; MicroRNAs - genetics; MicroRNAs - metabolism; Proto-Oncogene Proteins c-raf - genetics; Proto-Oncogene Proteins c-raf - metabolism; Research Paper; Sirtuins - genetics; Sirtuins - metabolism; Transfection; Up-Regulation; microRNA; cell proliferation; gene regulation; tumor; hepatocellular carcinoma

Human microRNA-125a-5p (miR-125a) is expressed in most tissues where it downregulates the expression of membrane receptors or intracellular transductors of mitogenic signals, thus limiting cell proliferation. Expression of this miRNA generally increases with cell differentiation whereas it is downre...