Fundamental understanding of drug absorption from a parenteral oil depot

• Published in: European journal of pharmaceutical sciences Vol. 83; pp. 19 - 27
• Main Authors: Kalicharan, Raween W., Schot, Peter, Vromans, Herman
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.02.2016
• Subjects: Absorbance; Absorption, Physiological; Aged; Aged, 80 and over; Androgens - administration & dosage; Androgens - blood; Androgens - chemistry; Androgens - pharmacokinetics; Benzyl alcohol; Benzyl Alcohol - administration & dosage; Benzyl Alcohol - blood; Benzyl Alcohol - chemistry; Benzyl Alcohol - pharmacokinetics; Dosage Forms; Female; Humans; Injections, Intramuscular; Injections, Subcutaneous; Nandrolone; Nandrolone - administration & dosage; Nandrolone - analogs & derivatives; Nandrolone - blood; Nandrolone - chemistry; Nandrolone - pharmacokinetics; Oil depots; Pharmacokinetics; Sesame Oil - administration & dosage; Sesame Oil - chemistry; Sesame Oil - pharmacokinetics; Viscosity; Nandrolone decanoate (PubChem CID: 9677); Benzyl alcohol (PubChem CID: 244); Testosterone decanoate (PubChem CID: 155143); Oil depots; Haloperidol decanoate (PubChem CID: 52919); Benzyl alcohol; P; Absorbance; Nandrolone phenyl propionate (PubChem CID: 229455); ND; Nandrolone; BOH; Cholecalciferol (PubChem CID: 5280795); Pharmacokinetics

Oil depots are parenteral drug formulations meant for sustained release of lipophilic compounds. Until now, a comprehensive understanding of the mechanism of drug absorption from oil depots is lacking. The aim of this paper was to fill this gap. A clinical study with healthy volunteers was conducted...