New insights into sperm with total globozoospermia: Increased fatty acid oxidation and centrin1 alteration

• Published in: Systems biology in reproductive medicine Vol. 65; no. 5; pp. 390 - 399
• Main Authors: Moretti, Elena, Collodel, Giulia, Salvatici, Maria Cristina, Belmonte, Giuseppe, Signorini, Cinzia
• Format: Journal Article
• Language: English
• Published: England 03.09.2019
• Subjects: Adult; Calcium-Binding Proteins - metabolism; Cell Cycle Proteins - metabolism; Centrioles; Fatty Acids - metabolism; Fertility; Humans; Male; Microscopy, Electrochemical, Scanning; Microscopy, Electron, Transmission; Spermatozoa - metabolism; Spermatozoa - ultrastructure; Teratozoospermia - pathology; phospholipase A; globozoospermia; Centrin1; F-isoprostanes; PPARγ

Sperm morphology and lipid profile have a relevant role in male fertility. We explore the status of the sperm centriole, essential structure for human fertilization and the role of fatty acid oxidation in globozoospermia, a rare sperm pathology causing infertility. A case of globozoospermia was char...