A polymorphism in the IL1B gene (rs16944 T/C) is associated with cutaneous leishmaniasis caused by Leishmania guyanensis and plasma cytokine interleukin receptor antagonist

• Published in: Cytokine (Philadelphia, Pa.) Vol. 123; p. 154788
• Main Authors: da Silva, George Allan Villarouco, de Mesquita, Tirza Gabrielle Ramos, de Souza Encarnação, Helia Valeria, do Espírito Santo Junior, José, da Costa Sabino, Karolina, de Aguiar Neres, Isaac, de Almeida, Salim Assad, de Souza, Mara Lúcia Gomes, Talhari, Sinésio, Ramasawmy, Rajendranath
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2019
• Subjects: Amazonas; Cutaneous Leishmaniasis; Leishmania guyanensis; Single nucleotide polymorphism, Interleukin-1 beta and Interleukin-1 receptor antagonist; Cutaneous Leishmaniasis; Single nucleotide polymorphism, Interleukin-1 beta and Interleukin-1 receptor antagonist; Amazonas; Leishmania guyanensis

•Leishmania activate the NLRP3 inflammasome in infected macrophages and enhance the secretion IL-1β.•Polymorphisms in IL1B and IL1RN genes are studied in 881 Cutaneous Leishmaniasis cases and 837 controls.•Plasma Cytokines IL-1B is higher among patients while IL1Ra in controls.•IL1B rs16944 is assoc...