IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling - Yu, Jinjin; Ming, Hong; Li, Henry You; Yu, Bin; Chu, Maoping; Zhu, Haibo; Zhu, Xinxing (Toxicology and applied pharmacology, 2019)
Keywords: Adenosine - analogs & derivatives; Adenosine - pharmacology; Anti-Inflammatory Agents - pharmacology; Atherosclerosis; Chemokine CCL2 - genetics; Chemokine CCL2 - metabolism; Cyclin D1 - genetics; Cyclin D1 - metabolism; Endothelium Inflammation; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; H007; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Interleukin-1beta - genetics; Interleukin-6 - genetics; Interleukin-6 - metabolism; JNK/c-Jun Signaling; MAP Kinase Kinase 4 - metabolism; NF-kappa B - metabolism; NF-κB Signaling; Signal Transduction - drug effects; THP-1 Cells; Transcription Factor AP-1 - metabolism; Vascular Cell Adhesion Molecule-1 - genetics; Vascular Cell Adhesion Molecule-1 - metabolism; Endothelium Inflammation; NF-κB Signaling; H007; JNK/c-Jun Signaling