Kynurenic acid ameliorates lipopolysaccharide-induced endometritis by regulating the GRP35/NF-κB signaling pathway

• Published in: Toxicology and applied pharmacology Vol. 438; p. 115907
• Main Authors: Wang, Ying, Liu, Zhuoyu, Shen, Peng, Zhao, Caijun, Liu, Bin, Shu, Chang, Hu, Xiaoyu, Fu, Yunhe
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2022
• Subjects: Animals; Cells, Cultured; Cytokines - metabolism; Endometritis; Endometritis - chemically induced; Endometritis - drug therapy; Endometritis - metabolism; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Female; Inflammatory response; Kynurenic acid; Kynurenic Acid - pharmacology; Lipopolysaccharides - pharmacology; LPS; Mice; Mice, Inbred BALB C; NF-kappa B - metabolism; Peroxidase - metabolism; Receptors, G-Protein-Coupled - metabolism; Signal Transduction - drug effects; Uterus - drug effects; Uterus - metabolism; Inflammatory response; Kynurenic acid; Endometritis; LPS

Endometritis is a serious reproductive disease in mammals that commonly results in reproductive loss and even permanent infertility. Kynurenic acid (KYNA) is the main bioactive metabolite of tryptophan degradation and exhibits neuroprotective and anticonvulsant properties. However, little is known a...