Toll-like receptors as diagnostic targets in pellucid marginal degeneration

• Published in: Experimental eye research Vol. 200; p. 108211
• Main Authors: Regueiro, Uxía, Pérez-Mato, María, Hervella, Pablo, Campos, Francisco, Sobrino, Tomás, Lema, Isabel
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2020
• Subjects: Adolescent; Adult; Aged; Child; Conjunctiva - metabolism; Conjunctiva - physiology; Cornea - metabolism; Cornea - pathology; Corneal ectasia; Corneal Topography; Female; Gene Expression Regulation; Humans; Innate immunity; Keratoconus; Keratoconus - diagnosis; Keratoconus - genetics; Keratoconus - metabolism; Male; Middle Aged; Pellucid marginal degeneration; Prospective Studies; RNA - genetics; ROC Curve; Toll-Like Receptors - biosynthesis; Toll-Like Receptors - genetics; Toll-like receptors 2; Toll-like receptors 4; Young Adult; Toll-like receptors 2; Innate immunity; Corneal ectasia; Keratoconus; Pellucid marginal degeneration; Toll-like receptors 4

The main purpose of this study is to evaluate the diagnostic role of Toll-like receptors 2 (TLR2) and 4 (TLR4) expression in corneal and conjunctival epithelial cells of eyes with pellucid marginal degeneration (PMD) compared to keratoconus patients (KC) and control subjects. A prospective case-cont...