Evaluation of proinflammatory and immunosuppressive cytokines in blood and bone marrow of healthy hematopoietic stem cell donors

• Published in: Cytokine (Philadelphia, Pa.) Vol. 102; pp. 181 - 186
• Main Authors: Fidyk, Wojciech, Mitrus, Iwona, Ciomber, Agnieszka, Smagur, Andrzej, Chwieduk, Agata, Głowala-Kosińska, Magdalena, Giebel, Sebastian
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2018
• Subjects: Adult; Bone marrow; Bone Marrow - immunology; Bone Marrow - metabolism; CD274; CD47; Cytokine levels; Cytokines - blood; Cytokines - metabolism; Female; Healthy Volunteers; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells - immunology; Hematopoietic Stem Cells - metabolism; Humans; Immune privilege; Immunosuppressive Agents - blood; Immunosuppressive Agents - metabolism; Inflammation Mediators - blood; Male; Middle Aged; Peripheral Blood Stem Cell Transplantation; Stem Cell Niche - immunology; Stem Cell Niche - physiology; Stem cells; Tissue Donors; Young Adult; CD274; IL; Tregs; GVHD; G-CSF; allo-HSCT; IFN-γ; TNF-α; Stem cells; PBSCs; Bone marrow; PD-L1; TGF-β1; Immune privilege; cGVHD; CD47; Cytokine levels
• ISSN: 1043-4666; 1096-0023; 1096-0023
• DOI: 10.1016/j.cyto.2017.09.001

•The first study comparing cytokine concentration, expression of CD47 and CD274 immunosuppressive proteins on HSCs in bone marrow and blood of hematopoietic stem cells donors.•Concentration of proinflammatory cytokines is higher in blood than in bone marrow.•TGFβ is present at very high concentratio...