Protein aggregation and crystallization with ionic liquids: Insights into the influence of solvent properties

• Published in: Journal of colloid and interface science Vol. 608; no. Pt 2; pp. 1173 - 1190
• Main Authors: Han, Qi, Brown, Stuart J., Drummond, Calum J., Greaves, Tamar L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.02.2022
• Subjects: Crystallization; Ionic Liquids; Protein Aggregates; Protein aggregation; Protein crystallization; Protic ionic liquids; Solvents; Water; Ionic liquids; Solvents; Protein aggregation; Protein crystallization; Protic ionic liquids

[Display omitted] Ionic liquids (ILs) have been used in solvents for proteins in many applications, including biotechnology, pharmaceutics, and medicine due to their tunable physicochemical and biological properties. Protein aggregation is often undesirable, and predominantly occurs during bioproces...