PIWIL2 stabilizes β-catenin to promote cell cycle and proliferation in tumor cells

• Published in: Biochemical and biophysical research communications Vol. 516; no. 3; pp. 819 - 824
• Main Authors: Qiu, Bojun, Zeng, Jiarong, Zhao, Xu, Huang, Lian, Ma, Tengjiao, Zhu, Yingchuan, Liu, Man, Tao, Dachang, Liu, Yunqiang, Lu, Yilu, Ma, Yongxin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.08.2019
• Subjects: GSK3β; PIWIL2; β-Catenin; β-Catenin/CyclinD1 pathway; PIWIL2; GSK3β; β-Catenin; β-Catenin/CyclinD1 pathway

PIWIL2 belongs to the PIWI protein subfamily and is widely expressed in a variety of tumors. Previous studies have shown that PIWIL2 has the characteristics of oncogene. Recently we reported that PIWIL2 suppresses GSK3β activity to regulate circadian rhythms through SRC-PI3K-AKT pathway. As GSK3β is...