Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma

• Published in: Neural regeneration research Vol. 7; no. 9; pp. 645 - 651
• Main Authors: Mi, Xue-Song, Chiu, Kin, Van, Geoffrey, Leung, Justin Wai Chung, Lo, Amy Cheuk Yin, Chung, Sookja Kim, Chang, Raymond Chuen-Chung, So, Kwok-Fai
• Format: Journal Article
• Language: English
• Published: India Medknow Publications & Media Pvt. Ltd 25.03.2012; The Joint Laborator; Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Department of Anatomy and the State Key Laboratory of Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China%Eye Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China%Department of Anatomy and the State Key Laboratory of Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Medknow Publications & Media Pvt Ltd
• Subjects: Apoptosis; Glaucoma; Hypertension; Ischemia; Lasers; Optic nerve; Pathogenesis; Research and Report: Traditional Chinese Medicine and Neuroregeneration; Retina; SD大鼠; Studies; 内皮素-1; 受体表达; 枸杞多糖; 模型; 眼压; 视网膜神经节细胞; 青光眼; Lycium barbarum Polysaccharides; endothelin-1; glaucoma; retinal ganglion cell

Lycium barbarum, a traditional Chinese anti-aging herb, has been shown to protect retinal ganglion cells （RGCs） in a rat chronic ocular hypertension （COH） model. Here, we investigated the expression of endothelin-1 （ET-1）, a strong vasoconstrictor, and its receptors, ETA and ETB, in the COH model an...