Response to direct-acting antiviral therapy among ongoing drug users and people receiving opioid substitution therapy

• Published in: Journal of hepatology Vol. 71; no. 1; pp. 45 - 51
• Main Authors: Macías, Juan, Morano, Luis E., Téllez, Francisco, Granados, Rafael, Rivero-Juárez, Antonio, Palacios, Rosario, Ríos, MªJosé, Merino, Dolores, Pérez-Pérez, Montserrat, Collado, Antonio, Figueruela, Blanca, Morano, Aitana, Freyre-Carrillo, Carolina, Martín, José M., Rivero, Antonio, García, Federico, Pineda, Juan A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2019
• Subjects: Adult; Antiviral Agents - administration & dosage; Antiviral Agents - adverse effects; Antiviral Agents - classification; Direct-acting antiviral agents; Drug-Related Side Effects and Adverse Reactions - diagnosis; Drug-Related Side Effects and Adverse Reactions - etiology; Female; HCV; Hepacivirus - drug effects; Hepacivirus - isolation & purification; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - etiology; Hepatitis C, Chronic - virology; HIV Infections - diagnosis; HIV Infections - drug therapy; Humans; Male; Medication Adherence; Opiate Substitution Treatment - methods; Opioid agonist therapy; Opioid-Related Disorders - therapy; Opioid-Related Disorders - virology; People who injected drugs; Substance Abuse, Intravenous - therapy; Substance Abuse, Intravenous - virology; Sustained Virologic Response; Treatment Outcome; Direct-acting antiviral agents; HCV; People who injected drugs; Opioid agonist therapy; Sustained virologic response

[Display omitted] •HCV-infected PWID achieve high SVR12 rates with IFN-free antiviral regimens in clinical practice.•PWID have lower SVR12 rates than patients who never used drugs.•Active drug use during antiviral treatment was an independent predictor of lower response, opioid agonist therapy was n...