Clinical trials of prion disease therapeutics

• Published in: Current opinion in pharmacology Vol. 44; pp. 53 - 60
• Main Authors: Forloni, Gianluigi, Roiter, Ignazio, Tagliavini, Fabrizio
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2019
• Subjects: Animals; Doxycycline - therapeutic use; Humans; Immunotherapy; Prion Diseases - diagnosis; Prion Diseases - prevention & control; Prion Diseases - therapy

Prion-related encephalopathies or transmissible spongiform encephalopathies (TSEs) are a group of rare progressive neurodegenerative disorders that are invariably fatal with often only six months elapsing from diagnosis to patient death. This makes the development of effective therapeutic strategies...