Tumor microenvironment: Challenges and opportunities in targeting metastasis of triple negative breast cancer

• Published in: Pharmacological research Vol. 153; p. 104683
• Main Authors: Deepak, K.G.K., Vempati, Rahul, Nagaraju, Ganji Purnachandra, Dasari, Venkata Ramesh, S., Nagini, Rao, D.N., Malla, Rama Rao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2020
• Subjects: Animals; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Apoptosis - drug effects; Chemoresistance; Epigenesis, Genetic; Exome - drug effects; Exome - immunology; Female; Humans; Metastasis; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplastic Stem Cells - drug effects; Phytochemicals; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - genetics; Triple Negative Breast Neoplasms - immunology; Triple Negative Breast Neoplasms - pathology; Tumor Microenvironment - drug effects; Tumor Microenvironment - genetics; Tumor Microenvironment - immunology; Tumor microenvironment and TNBC; Phytochemicals; Metastasis; Tumor microenvironment and TNBC; Chemoresistance

[Display omitted] •TNBC is highly challenging subtype of breast cancer due to unique tumor microenvironment (TME).•TME associates with aggressive nature, metastasis and drug resistance in TNBC.•Epigenetic based regulations within TME drive carcinogenesis.•Novel therapeutic targets of TME helps in ea...