A PET/MR Imaging Approach for the Integrated Assessment of Chemotherapy-induced Brain, Heart, and Bone Injuries in Pediatric Cancer Survivors: A Pilot Study

• Published in: Radiology Vol. 285; no. 3; pp. 971 - 979
• Main Authors: Theruvath, Ashok J., Ilivitzki, Anat, Muehe, Anne, Theruvath, Johanna, Gulaka, Praveen, Kim, Christine, Luna-Fineman, Sandra, Sakamoto, Kathleen M., Yeom, Kristen W., Yang, Phillip, Moseley, Michael, Chan, Frandics, Daldrup-Link, Heike E.
• Format: Journal Article
• Language: English
• Published: United States Radiological Society of North America 01.12.2017
• Subjects: Adolescent; Antineoplastic Agents - adverse effects; Bone Diseases - chemically induced; Bone Diseases - diagnostic imaging; Brain Diseases - chemically induced; Brain Diseases - diagnostic imaging; Cancer Survivors; Female; Heart Diseases - chemically induced; Heart Diseases - diagnostic imaging; Humans; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - statistics & numerical data; Male; Multimodal Imaging; Neoplasms - diagnostic imaging; Neoplasms - drug therapy; Observer Variation; Original Research; Positron-Emission Tomography - methods; Reproducibility of Results; Risk Factors; Sensitivity and Specificity; Systems Integration; Treatment Outcome; Young Adult

Purpose To develop a positron emission tomography (PET)/magnetic resonance (MR) imaging protocol for evaluation of the brain, heart, and joints of pediatric cancer survivors for chemotherapy-induced injuries in one session. Materials and Methods Three teams of experts in neuroimaging, cardiac imagin...