Synthesis of 2-[ 123I and 124I]-iodoisonicotinic acid hydrazide—potential radiotracers for tuberculosis

• Published in: International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes Vol. 42; no. 3; pp. 215 - 220
• Main Authors: Somawardhana, C.W., Sajjad, M., Amartey, J.K., Lambrecht, R.M.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier B.V 1991; Pergamon
• Subjects: Animals; Biological Availability; Brain Diseases - diagnostic imaging; Chemistry; Exact sciences and technology; Heterocyclic compounds; Heterocyclic compounds with only one n hetero atom and condensed derivatives; Iodine Radioisotopes; Isoniazid - analogs & derivatives; Isoniazid - chemical synthesis; Isoniazid - pharmacokinetics; Isonicotinic Acids - chemical synthesis; Isonicotinic Acids - pharmacokinetics; Isotope Labeling - methods; Male; Organic chemistry; Preparations and properties; Radiochemistry; Radionuclide Imaging; Rats; Rats, Inbred Strains; Tuberculoma - diagnostic imaging; Organic hydrazide; Iodine Isotopes; Nitrogen heterocycle; Labelled compound; Halogen Organic compounds

The radiochemical syntheses of methyl 2-[ 123I]-iodoisonicotinate, 2-[ 123I]-iodoisonicotinic acid hydrazide and 2-[ 124I]-iodoisonicotinic acid hydrazide was accomplished. Iodine-123 was incorporated in the methyl ester molecule by an exchange reaction in glacial acetic acid. The average efficiency...