A series of simple detection systems for genetic variants of flavin-containing monooxygenase 3 (FMO3) with impaired function in Japanese subjects

• Published in: Drug metabolism and pharmacokinetics Vol. 41; p. 100420
• Main Authors: Shimizu, Makiko, Mizugaki, Ami, Koibuchi, Natsumi, Sango, Haruna, Uenuma, Yumi, Yamazaki, Hiroshi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2021
• Subjects: Allele-specific PCR; Alleles; FMO3; Humans; Japan; Metabolism, Inborn Errors - genetics; Oxygenases - genetics; PCR-RFLP; Single-nucleotide substitutions; Japan; Allele-specific PCR; PCR-RFLP; FMO3; Single-nucleotide substitutions
• ISSN: 1347-4367; 1880-0920; 1880-0920
• DOI: 10.1016/j.dmpk.2021.100420

Increasing numbers of single-nucleotide substitutions of the human flavin-containing monooxygenase 3 (FMO3) gene are being recorded in mega-databases. Phenotype–gene analyses revealed impaired FMO3 variants associated with the metabolic disorder trimethylaminuria. Here, a series of reliable FMO3 gen...