Anti-CLL1 Chimeric Antigen Receptor T-Cell Therapy in Children with Relapsed/Refractory Acute Myeloid Leukemia

• Published in: Clinical cancer research Vol. 27; no. 13; pp. 3549 - 3555
• Main Authors: Zhang, Hui, Wang, Pengfei, Li, Zhuoyan, He, Yingyi, Gan, Wenting, Jiang, Hua
• Format: Journal Article
• Language: English
• Published: United States 01.07.2021
• Subjects: Cell- and Tissue-Based Therapy; Child; Humans; Immunotherapy, Adoptive - adverse effects; Leukemia, Myeloid, Acute - genetics; Leukocytes, Mononuclear; Receptors, Chimeric Antigen

The survival rate of children with refractory/relapsed acute myeloid leukemia (R/R-AML) by salvage chemotherapy is minimal. Treatment with chimeric antigen receptor T cells (CAR T) has emerged as a novel therapy to improve malignancies treatment. C-type lectin-like molecule 1 (CLL1) is highly expres...