Api5 a new cofactor of estrogen receptor alpha involved in breast cancer outcome

• Published in: Oncotarget Vol. 8; no. 32; pp. 52511 - 52526
• Main Authors: Basset, Céline, Bonnet-Magnaval, Florence, Navarro, Marina Garcia-Jove, Touriol, Christian, Courtade, Monique, Prats, Hervé, Garmy-Susini, Barbara, Lacazette, Eric
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 08.08.2017
• Subjects: Research Paper; apoptosis inhibitor 5; breast cancer; tumorigenesis; co-factor; estrogen receptor alpha

Api5 (Apoptosis inhibitor 5) is an anti-apoptotic factor that confers resistance to genotoxic stress in human cancer. Api5 is also expressed in endothelial cells and participates to the Estrogen Receptor α (ERα) signaling to promote cell migration. In this study, we found an over expression of Api5...