Evaluation of plasma activity of matrix metalloproteinase-2 and -9 in dogs with myxomatous mitral valve disease

• Published in: American journal of veterinary research Vol. 72; no. 8; pp. 1022 - 1028
• Main Authors: Ljungvall, Ingrid, Rajamaki, Minna M, Crosara, Serena, Olsen, Lisbeth H, Kvart, Clarence, Borgarelli, Michele, Hoglund, Katja, Haggstrom, Jens
• Format: Journal Article
• Language: English
• Published: United States 01.08.2011
• Subjects: Animals; Biomarkers; Blood Pressure; C-reactive protein; C-Reactive Protein - analysis; Dog Diseases - blood; Dog Diseases - pathology; Dog Diseases - physiopathology; Dogs; echocardiography; Echocardiography - veterinary; Electrophoresis, Polyacrylamide Gel - veterinary; Enzyme Precursors - blood; Enzyme Precursors - metabolism; enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - veterinary; Female; gelatinase A; Heart - physiopathology; Heart Rate; Male; Matrix Metalloproteinase 2 - blood; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - blood; Matrix Metalloproteinase 9 - metabolism; Mitral Valve - pathology; Mitral Valve Insufficiency - blood; Mitral Valve Insufficiency - pathology; Mitral Valve Insufficiency - physiopathology; Mitral Valve Insufficiency - veterinary; Multivariate Analysis; Regression Analysis; Sensitivity and Specificity; Severity of Illness Index; Species Specificity; Troponin I - blood

Objective—To investigate whether plasma activity of matrix metalloproteinase (MMP)-2 and -9 was associated with severity of myxomatous mitral valve disease (MMVD) in dogs and to assess potential associations between MMP activity and dog characteristics, echocardiographic variables, systolic arterial...