Circumventing glass vial and diluent effects on solution stability of small molecule analytes during analytical method development and validation

Solution stability of analytes plays an important part in qualitative analysis, especially in conducting accurate, quantitative analyses. Sample diluents and glass vials as sample containers for HPLC analyses can play a critical role and should be evaluated during chromatographic method development....

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Bibliographic Details
Published inJournal of pharmaceutical and biomedical analysis Vol. 213; p. 114676
Main Authors Huang, Yande, Hu, Yue, Yuill, Elizabeth M., Marriott, Andrew S., Chadwick, James, Li, Jieming, Zang, Jia, Miller, Scott A.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 10.05.2022
Subjects
Adsorption
Chromatography, High Pressure Liquid
Drug Packaging - methods
Excipients
Glass - chemistry
Glass vials
Peracetylated C-aryl glucosides
Piperazine
Reproducibility of Results
Silanols
Adsorption
Piperazine
Silanols
Peracetylated C-aryl glucosides
Glass vials
Online AccessGet full text
ISSN0731-7085
1873-264X
1873-264X
DOI10.1016/j.jpba.2022.114676

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