Characteristics of contents in the upper gastrointestinal lumen after a standard high-calorie high-fat meal and implications for the in vitro drug product performance testing conditions

• Published in: European journal of pharmaceutical sciences Vol. 155; p. 105535
• Main Authors: Pentafragka, Christina, Vertzoni, Maria, Dressman, Jennifer, Symillides, Mira, Goumas, Konstantinos, Reppas, Christos
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2020
• Subjects: Adult; Biorelevant media; Cross-Over Studies; Fed state; Humans; Intestine, Small; Male; Micellar phase; Osmolar Concentration; Pharmaceutical Preparations; Physicochemical characteristics; Stomach; Upper gastrointestinal lumen; Viscosity; Viscosity; Micellar phase; Biorelevant media; Physicochemical characteristics; Fed state; Upper gastrointestinal lumen

To measure the pH, buffer capacity, lipid content, bile acid content, and viscosity in the upper gastrointestinal (GI) lumen after a standard high-calorie, high-fat meal as well as the osmolality, lipid content and bile acid content in the aqueous phase of the gastric contents and the micellar phase...