S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells

• Published in: Nitric oxide Vol. 84; pp. 22 - 29
• Main Authors: Tsuneyoshi, Tadamitsu, Kunimura, Kayo, Morihara, Naoaki
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2019
• Subjects: Bach1; Basic-Leucine Zipper Transcription Factors - genetics; Basic-Leucine Zipper Transcription Factors - metabolism; Cysteine - analogs & derivatives; Cysteine - pharmacology; Down-Regulation; Garlic; Glutamate-Cysteine Ligase - metabolism; Heme Oxygenase-1 - genetics; Heme Oxygenase-1 - metabolism; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Hydroxylamines - pharmacology; NF-E2-Related Factor 2 - metabolism; Nitric oxide; Nitric Oxide - metabolism; Nrf2; S-1-Propenylcysteine; Signal Transduction - drug effects; Up-Regulation; NO; AREs; Bach1; tBHQ; S-1-Propenylcysteine; NOR3; HAECs; GSNO; SAC; Nrf2; Nitric oxide; S1PC; ROS; Garlic; LeptB; NO-donor; HUVECs

Garlic has been demonstrated to exert protective effects against oxidative damage using numerous experimental models. The antioxidant effects of garlic are associated with the activation of Nrf2-dependent gene expression. S-1-Propenylcysteine (S1PC) and S-allylcysteine (SAC) are two predominant sulf...