Acute and repeated exposure with the nitric oxide (NO) donor sodium nitroprusside (SNP) differentially modulate responses in a rat model of anxiety

• Published in: Nitric oxide Vol. 69; pp. 56 - 60
• Main Authors: Orfanidou, Martha A., Lafioniatis, Anastasios, Trevlopoulou, Aikaterini, Touzlatzi, Ntilara, Pitsikas, Nikolaos
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.09.2017
• Subjects: Animals; Anxiety; Anxiety - drug therapy; Light/dark test; Locomotion - drug effects; Male; Nitric oxide; Nitric Oxide Donors - administration & dosage; Nitric Oxide Donors - therapeutic use; Nitroprusside - administration & dosage; Nitroprusside - therapeutic use; Rat; Rats, Wistar; Sodium nitroprusside; Time and Motion Studies; Sodium nitroprusside; Anxiety; Rat; Light/dark test; Nitric oxide

The nitric oxide (NO) donor sodium nitroprusside (SNP) actually is under investigation for the treatment of schizophrenia. That anxiety disorders are noted to occur commonly in schizophrenia patients is known. Contradictory results were reported however, concerning the effects of SNP in animal model...