Lack of association of TNFα gene polymorphisms and recurrent pregnancy loss in Caucasian women
The tumor necrosis factor alpha (TNFα) gene plays an important role in immunology and inflammation. Variant alleles of TNFα are associated with altered RNA and serum protein levels in humans. Conflicting results have been obtained regarding the role of TNFα during pregnancy and recurrent pregnancy l...
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| Published in | Journal of reproductive immunology Vol. 61; no. 1; pp. 51 - 58 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier Ireland Ltd
01.02.2004
Elsevier Science |
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| Abstract | The tumor necrosis factor alpha (TNFα) gene plays an important role in immunology and inflammation. Variant alleles of TNFα are associated with altered RNA and serum protein levels in humans. Conflicting results have been obtained regarding the role of TNFα during pregnancy and recurrent pregnancy loss (RPL). This study investigated the relationship between RPL and two polymorphisms in the promoter of the TNFα gene (TNFα −308 and −863). Genotyping was performed in 168 RPL women and 212 ethnically matched healthy individuals. In addition, we performed analysis of TNFα serum protein levels. We demonstrate that neither the polymorphism −308 nor the polymorphism −863 of the TNFα gene is associated with RPL in Caucasian women. In addition, we did not find any association between TNFα serum levels and the occurrence of RPL in a subset of 36 RPL women and 36 healthy individuals. We conclude that TNFα polymorphisms and resting blood TNFα levels do not correlate with the propensity to recurrent pregnancy loss in Caucasian women. |
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| AbstractList | The tumor necrosis factor alpha (TNFα) gene plays an important role in immunology and inflammation. Variant alleles of TNFα are associated with altered RNA and serum protein levels in humans. Conflicting results have been obtained regarding the role of TNFα during pregnancy and recurrent pregnancy loss (RPL). This study investigated the relationship between RPL and two polymorphisms in the promoter of the TNFα gene (TNFα −308 and −863). Genotyping was performed in 168 RPL women and 212 ethnically matched healthy individuals. In addition, we performed analysis of TNFα serum protein levels. We demonstrate that neither the polymorphism −308 nor the polymorphism −863 of the TNFα gene is associated with RPL in Caucasian women. In addition, we did not find any association between TNFα serum levels and the occurrence of RPL in a subset of 36 RPL women and 36 healthy individuals. We conclude that TNFα polymorphisms and resting blood TNFα levels do not correlate with the propensity to recurrent pregnancy loss in Caucasian women. The tumor necrosis factor alpha (TNF alpha ) gene plays an important role in immunology and inflammation. Variant alleles of TNF alpha are associated with altered RNA and serum protein levels in humans. Conflicting results have been obtained regarding the role of TNF alpha during pregnancy and recurrent pregnancy loss (RPL). This study investigated the relationship between RPL and two polymorphisms in the promoter of the TNF alpha gene (TNF alpha -308 and -863). Genotyping was performed in 168 RPL women and 212 ethnically matched healthy individuals. In addition, we performed analysis of TNF alpha serum protein levels. We demonstrate that neither the polymorphism -308 nor the polymorphism -863 of the TNF alpha gene is associated with RPL in Caucasian women. In addition, we did not find any association between TNF alpha serum levels and the occurrence of RPL in a subset of 36 RPL women and 36 healthy individuals. We conclude that TNF alpha polymorphisms and resting blood TNF alpha levels do not correlate with the propensity to recurrent pregnancy loss in Caucasian women. |
| Author | Pietrowski, Detlef Bürkle, Bernd Unfried, Gertrud Keck, Christoph Hefler, Lukas A Tempfer, Clemens Riener, Eva-Katrin Bettendorf, Herta |
| Author_xml | – sequence: 1 givenname: Detlef surname: Pietrowski fullname: Pietrowski, Detlef email: pietrowski@frk.ukl.uni-freiburg.de organization: Department of Gynecology and Obstetrics, University of Freiburg School of Medicine, Freiburg, Germany – sequence: 2 givenname: Herta surname: Bettendorf fullname: Bettendorf, Herta organization: Department of Gynecology and Obstetrics, University of Freiburg School of Medicine, Freiburg, Germany – sequence: 3 givenname: Christoph surname: Keck fullname: Keck, Christoph organization: Department of Gynecology and Obstetrics, University of Freiburg School of Medicine, Freiburg, Germany – sequence: 4 givenname: Bernd surname: Bürkle fullname: Bürkle, Bernd organization: Department of Gynecology and Obstetrics, University of Freiburg School of Medicine, Freiburg, Germany – sequence: 5 givenname: Gertrud surname: Unfried fullname: Unfried, Gertrud organization: Department of Gynecology and Obstetrics, University of Vienna School of Medicine, Vienna, Austria – sequence: 6 givenname: Eva-Katrin surname: Riener fullname: Riener, Eva-Katrin organization: Department of Gynecology and Obstetrics, University of Freiburg School of Medicine, Freiburg, Germany – sequence: 7 givenname: Lukas A surname: Hefler fullname: Hefler, Lukas A organization: Department of Gynecology and Obstetrics, University of Vienna School of Medicine, Vienna, Austria – sequence: 8 givenname: Clemens surname: Tempfer fullname: Tempfer, Clemens organization: Department of Gynecology and Obstetrics, University of Freiburg School of Medicine, Freiburg, Germany |
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| CitedBy_id | crossref_primary_10_1371_journal_pone_0108287 crossref_primary_10_1186_1477_7827_8_114 crossref_primary_10_1111_j_1479_828X_2008_00843_x crossref_primary_10_1016_j_fertnstert_2008_01_090 crossref_primary_10_1080_14647273_2018_1543899 crossref_primary_10_1002_ijgo_15575 crossref_primary_10_1007_s13224_023_01933_x crossref_primary_10_1016_j_cyto_2012_05_018 crossref_primary_10_1177_1933719110366603 crossref_primary_10_1016_j_siny_2006_03_001 crossref_primary_10_3390_ijms24010132 crossref_primary_10_1016_S1472_6483_10_62018_4 crossref_primary_10_1111_j_1600_0897_2008_00602_x crossref_primary_10_1186_s12958_016_0140_6 crossref_primary_10_1016_j_cca_2011_01_002 crossref_primary_10_1097_01_gco_0000193011_73405_07 crossref_primary_10_1016_S1472_6483_10_60176_9 crossref_primary_10_1530_REP_07_0322 crossref_primary_10_1177_1933719107305213 crossref_primary_10_1371_journal_pone_0166892 crossref_primary_10_1016_j_jri_2021_103430 crossref_primary_10_1016_j_humimm_2012_01_008 crossref_primary_10_1016_j_jri_2009_12_005 |
| Cites_doi | 10.1016/S0165-0378(02)00059-1 10.1006/cimm.1999.1532 10.1016/S0015-0282(16)58382-4 10.1034/j.1600-0897.2002.01105.x 10.1016/S0301-2115(98)00252-8 10.1164/ajrccm.163.2.2002062 10.1073/pnas.94.7.3195 10.1097/00007890-200004150-00054 10.1093/humrep/17.8.1959 10.1093/hmg/8.8.1443 10.1111/j.8755-8920.2001.450106.x 10.1093/humrep/15.3.713 10.1530/eje.0.1460629 10.1056/NEJM200002243420802 10.1001/jama.273.24.1933 10.1016/0165-0378(94)90026-4 10.1016/S0165-0378(01)00069-9 10.1016/S0015-0282(00)00517-3 10.1111/j.1471-0528.1997.tb11009.x |
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| Keywords | Pregnancy TNFα Genetic study Miscarriage Polymorphism Pregnancy disorders Cytokine Abortion Vertebrata Mammalia Gene Female Genetics Tumor necrosis factor α |
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| Snippet | The tumor necrosis factor alpha (TNFα) gene plays an important role in immunology and inflammation. Variant alleles of TNFα are associated with altered RNA and... The tumor necrosis factor alpha (TNF alpha ) gene plays an important role in immunology and inflammation. Variant alleles of TNF alpha are associated with... |
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| SubjectTerms | Biological and medical sciences Embryology: invertebrates and vertebrates. Teratology Fundamental and applied biological sciences. Psychology Genetic study Miscarriage Polymorphism Pregnancy TNFα |
| Title | Lack of association of TNFα gene polymorphisms and recurrent pregnancy loss in Caucasian women |
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