The effects of the CXCR2 antagonist, MK-7123, on bone marrow functions in healthy subjects

• Published in: Cytokine (Philadelphia, Pa.) Vol. 72; no. 2; pp. 197 - 203
• Main Authors: Hastrup, Nina, Khalilieh, Sauzanne, Dale, David C., Hanson, Lars G., Magnusson, Peter, Tzontcheva, Anjela, Tseng, Jack, Huyck, Susan, Rosenberg, Elizabeth, Krogsgaard, Kim
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2015
• Subjects: Adolescent; Adult; Aged; Benzamides - administration & dosage; Benzamides - adverse effects; Bone marrow; Bone Marrow - drug effects; Bone Marrow Cells - drug effects; Bone Marrow Examination; CXCR2; Cyclobutanes - administration & dosage; Cyclobutanes - adverse effects; Double-Blind Method; Flow Cytometry; Healthy Volunteers; Humans; Leukocyte Count; Male; Middle Aged; Mitotic Index; MK-7123; Myelopoiesis; Neutropenia - chemically induced; Neutrophil; Neutrophils - drug effects; Neutrophils - physiology; Receptors, Interleukin-8B - antagonists & inhibitors; Young Adult; Bone marrow; Neutrophil; Myelopoiesis; MK-7123; CXCR2

•CXCR2 antagonists such as MK-7123 may be useful anti-inflammatory agents.•MK-7123 results in a reversible decline in absolute neutrophil counts (ANC).•The mechanism of neutrophil decline is unknown.•The effect of MK-7123 on myelopoiesis was evaluated as a mechanism of ANC decline.•The decrease in A...