The miR-143/145 cluster reverses the regulation effect of KLF5 in smooth muscle cells with proliferation and contractility in intracranial aneurysm

• Published in: Gene Vol. 679; pp. 266 - 273
• Main Authors: Xu, Jichong, Yan, Shuo, Tan, Huaqiao, Ma, Lin, Feng, Hao, Han, Hongjie, Pan, Minmin, Yu, Limin, Fang, Chun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.12.2018
• Subjects: Intracranial aneurysm; KLF5; miR-143; miR-145; Smooth muscle cells; Rt-PCR; VSMCs; KLF5; miR-143; Intracranial aneurysm; miR-145; miRNA; IAs; siRNA; Smooth muscle cells

Alterations in vascular smooth muscle cells (VSMCs) contribute to the pathogenesis of intracranial aneurysms (IAs), but the molecular mechanisms of these alterations are unclear. The aim of this study was therefore to identify the molecular mechanism of VSMC-mediated IAs at clinical and cellular lev...