In vivo imaging of serotonin transporter occupancy by means of SPECT and [123I]ADAM in healthy subjects administered different doses of escitalopram or citalopram

• Published in: Psychopharmacologia Vol. 188; no. 3; pp. 263 - 272
• Main Authors: Klein, N., Sacher, J., Geiss-Granadia, T., Attarbaschi, T., Mossaheb, N., Lanzenberger, R., Pötzi, C., Holik, A., Spindelegger, C., Asenbaum, S., Dudczak, R., Tauscher, J., Kasper, S.
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.10.2006; Springer Nature B.V
• Subjects: Administration, Oral; Adult; Akathisia, Drug-Induced - etiology; Area Under Curve; Biological and medical sciences; Cerebellum - diagnostic imaging; Cerebellum - drug effects; Cerebellum - metabolism; Cinanserin - administration & dosage; Cinanserin - analogs & derivatives; Citalopram - administration & dosage; Citalopram - pharmacokinetics; Citalopram - pharmacology; Clinical trials; Dose-Response Relationship, Drug; Humans; Inhibitor drugs; Iodine Radioisotopes; Male; Medical sciences; Mental disorders; Mesencephalon - diagnostic imaging; Mesencephalon - drug effects; Mesencephalon - metabolism; Metabolic Clearance Rate; Nausea - chemically induced; Neuropharmacology; Pharmacology; Pharmacology. Drug treatments; Protein Binding; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Psychotropic drugs; Scientific imaging; Serotonin Plasma Membrane Transport Proteins - metabolism; Serotonin Uptake Inhibitors - administration & dosage; Serotonin Uptake Inhibitors - pharmacokinetics; Serotonin Uptake Inhibitors - pharmacology; Sleep Wake Disorders - chemically induced; Stereoisomerism; Time Factors; Tomography, Emission-Computed, Single-Photon - methods; Xerostomia - chemically induced; Human; Serotonin; Healthy subject; Escitalopram; Psychotropic; Reuptake inhibitor; Photon; SPECT; Citalopram; Selective serotonin reuptake inhibitor; In vivo; SSRI; Serotonin transporter; Imaging; Neurotransmitter; Antidepressant agent; Medical imagery; Serotonin reuptake transporter; Emission tomography

Escitalopram is a dual serotonin reuptake inhibitor (SSRI) approved for the treatment of depression and anxiety disorders. It is the S-enantiomer of citalopram, and is responsible for the serotonin reuptake activity, and thus for its pharmacological effects. Previous studies pointed out that clinica...