In vivo imaging of serotonin transporter occupancy by means of SPECT and [123I]ADAM in healthy subjects administered different doses of escitalopram or citalopram - Klein, N.; Sacher, J.; Geiss-Granadia, T.; Attarbaschi, T.; Mossaheb, N.; Lanzenberger, R.; Pötzi, C.; Holik, A.; Spindelegger, C.; Asenbaum, S.; Dudczak, R.; Tauscher, J.; et al. (Psychopharmacologia, 2006)
Keywords: Administration, Oral; Adult; Akathisia, Drug-Induced - etiology; Area Under Curve; Biological and medical sciences; Cerebellum - diagnostic imaging; Cerebellum - drug effects; Cerebellum - metabolism; Cinanserin - administration & dosage; Cinanserin - analogs & derivatives; Citalopram - administration & dosage; Citalopram - pharmacokinetics; Citalopram - pharmacology; Clinical trials; Dose-Response Relationship, Drug; Humans; Inhibitor drugs; Iodine Radioisotopes; Male; Medical sciences; Mental disorders; Mesencephalon - diagnostic imaging; Mesencephalon - drug effects; Mesencephalon - metabolism; Metabolic Clearance Rate; Nausea - chemically induced; Neuropharmacology; Pharmacology; Pharmacology. Drug treatments; Protein Binding; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Psychotropic drugs; Scientific imaging; Serotonin Plasma Membrane Transport Proteins - metabolism; Serotonin Uptake Inhibitors - administration & dosage; Serotonin Uptake Inhibitors - pharmacokinetics; Serotonin Uptake Inhibitors - pharmacology; Sleep Wake Disorders - chemically induced; Stereoisomerism; Time Factors; Tomography, Emission-Computed, Single-Photon - methods; Xerostomia - chemically induced; Human; Serotonin; Healthy subject; Escitalopram; Psychotropic; Reuptake inhibitor; Photon; SPECT; Citalopram; Selective serotonin reuptake inhibitor; In vivo; SSRI; Serotonin transporter; Imaging; Neurotransmitter; Antidepressant agent; Medical imagery; Serotonin reuptake transporter; Emission tomography