A Phase 1 Study to Evaluate the Effect of Crushing, Cutting Into Half, or Grinding of Glecaprevir/Pibrentasvir Tablets on Exposures in Healthy Subjects - Oberoi, Rajneet K.; Zhao, Weihan; Sidhu, Dilraj S.; Viani, Rolando M.; Trinh, Roger; Liu, Wei (Journal of pharmaceutical sciences, 2018)
Keywords: Adult; anti-infectives; Antiviral Agents - administration & dosage; Antiviral Agents - adverse effects; Antiviral Agents - blood; Area Under Curve; Benzimidazoles - administration & dosage; Benzimidazoles - adverse effects; Benzimidazoles - blood; bioavailability; Biological Availability; clinical pharmacokinetics; Cross-Over Studies; Female; formulation; Humans; Male; Middle Aged; oral absorption; Particle Size; pharmacokinetics; Quinoxalines - administration & dosage; Quinoxalines - adverse effects; Quinoxalines - blood; Sulfonamides - administration & dosage; Sulfonamides - adverse effects; Sulfonamides - blood; Tablets; GLE; Cmax; DAA; RBV; PIB; anti-infectives; GT; AUC; bioavailability; t1/2; Tmax; clinical pharmacokinetics; formulation; pharmacokinetics; HCV; oral absorption