Synthesis of novel spiro[pyrazolo[4,3-d]pyrimidinones and spiro[benzo[4,5]thieno[2,3-d]pyrimidine-2,3′-indoline]-2′,4(3H)-diones and their evaluation for anticancer activity

• Published in: Bioorganic & medicinal chemistry letters Vol. 27; no. 6; pp. 1446 - 1450
• Main Authors: Ismail, Kuthati, Bhaskar, Thalari, Gangadhar, Bommarapu, Venkatesham, Mulakayala, Chaitanya, Chitta, Suresh Kumar, Mulakayala, Naveen
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.03.2017; Elsevier
• Subjects: 4-Amino-1-methyl-3-propylpyrazole-5-carboxamide; Anticancer agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line, Tumor; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Drug Screening Assays, Antitumor; Humans; InCl3; Life Sciences & Biomedicine; Mass Spectrometry; Pharmacology & Pharmacy; Physical Sciences; Proton Magnetic Resonance Spectroscopy; Pyrimidines - chemical synthesis; Pyrimidines - chemistry; Pyrimidines - pharmacology; Science & Technology; Spiro[benzo[4,5]thieno[2,3-d]pyrimidine-2,3′-indoline]-2′,4(3H)-dione; Spiro[pyrazolo[4,3-d]pyrimidin]-7′(1′H)-ones; Spiro[pyrazolo[4,3-d]pyrimidin]-7′(1′H)-ones; InCl3; Spiro[benzo[4,5]thieno[2,3-d]pyrimidine-2,3′-indoline]-2′,4(3H)-dione; Anticancer agents; 4-Amino-1-methyl-3-propylpyrazole-5-carboxamide; Spiro[pyrazolo[4,3-d]pyrimidin]-7 '(I ' H)-ones; Spiro[benzo[4,5]thieno[2,3-d]pyrimidine-2,3 '-indoline]-2 ',4(3H)-dione; SIRTUINS; DERIVATIVES; CANCER; SIRT1; InCl

[Display omitted] An efficient and novel method for the preparation of spiro[pyrazolo[4,3-d]pyrimidin]-7′(1′H)-ones by the condensation of 4-amino-1-methyl-3-propylpyrazole-5-carboxamide with ketones under mild conditions using catalytic InCl3 was reported. This method has been extended for the synt...