A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior

• Published in: Cell host & microbe Vol. 32; no. 2; pp. 227 - 243.e6
• Main Authors: Cheng, Lingsha, Wu, Haoqian, Cai, Xiaoying, Zhang, Youying, Yu, Siqi, Hou, Yuanlong, Yin, Zhe, Yan, Qingyuan, Wang, Qiong, Sun, Taipeng, Wang, Guangji, Yuan, Yonggui, Zhang, Xueli, Hao, Haiping, Zheng, Xiao
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.02.2024
• Subjects: Animals; Bacteroidetes; Brain; depressive disorder; Gastrointestinal Microbiome - physiology; genetic risk; Gpr35; gut microbiome; gut-brain axis; indole-3-carboxaldehyde; indole-3-lactate; Mice; Microbiota; neural plasticity; Parabacteroides distasonis; tryptophan metabolism; Parabacteroides distasonis; gut microbiome; tryptophan metabolism; indole-3-lactate; neural plasticity; Gpr35; genetic risk; depressive disorder; gut-brain axis; indole-3-carboxaldehyde

Gene-environment interactions shape behavior and susceptibility to depression. However, little is known about the signaling pathways integrating genetic and environmental inputs to impact neurobehavioral outcomes. We report that gut G-protein-coupled receptor, Gpr35, engages a microbe-to-brain metab...