Expression pattern of miR-21, miR-25 and PTEN in peripheral blood mononuclear cells of patients with significant or insignificant coronary stenosis

• Published in: Gene Vol. 698; pp. 170 - 178
• Main Authors: Nariman-saleh-fam, Ziba, Vahed, Sepideh Zununi, Aghaee-Bakhtiari, Seyed Hamid, Daraei, Abdolreza, Saadatian, Zahra, Kafil, Hossein Samadi, Yousefi, Bahman, Eyvazi, Shirin, Khaheshi, Isa, Parsa, Saeed Alipour, Moravej, Ali, Mousavi, Negar, Bastami, Milad, Mansoori, Yaser
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.05.2019
• Subjects: Aged; Aged, 80 and over; Atherosclerosis; Biomarkers - blood; Blood; Case-Control Studies; Coronary Stenosis - blood; Coronary Stenosis - genetics; Endothelial Cells - metabolism; Female; Gene expression; Humans; Leukocytes - metabolism; Leukocytes, Mononuclear - metabolism; Male; MicroRNA; MicroRNAs - biosynthesis; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; miRNA; PTEN Phosphohydrolase - biosynthesis; PTEN Phosphohydrolase - blood; PTEN Phosphohydrolase - genetics; NSTEMI; SAP; UAP; CAD; ROC; GS; Gene expression; PBMC; Blood; MicroRNA; Atherosclerosis; miRNA; AMI; ICAD

Coronary artery disease (CAD) is primarily caused by atherosclerosis, which is a series of chronic inflammatory processes leading to the initiation and progression of vascular endothelial cell injury enhancing plaque formation. As critical components of the immune system, peripheral blood mononuclea...