Preclusion of methemoglobinemia caused by nitrate drugs in diabetics and nondiabetics: Possible role of Vitamin C

• Published in: Blood cells, molecules, & diseases Vol. 94; p. 102643
• Main Authors: Das, Debashree, Sen, Souvik, Bhakta, Santanu, Sen, Kamalika
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2022
• Subjects: Ascorbic Acid - therapeutic use; Diabetes Mellitus - drug therapy; Fasting insulin; Humans; Methemoglobinemia; Methemoglobinemia - chemically induced; Methemoglobinemia - prevention & control; Nitrate drugs; Nitrates - adverse effects; Serum glucose; Vitamin C; Serum glucose; Methemoglobinemia; Fasting insulin; Nitrate drugs; Vitamin C

The drugs containing nitrates like isosorbide dinitrate, isosorbide mononitrate and glyceryl trinitrate, etc., trigger the oxidation of hemoglobin which is manifested in the pathological disorder named methemoglobinemia. It was considered interesting to investigate the preventive roles of vitamin C...