Latency of epoxide hydratase and its relationship to that of udpglucuronyltransferase

• Published in: Biochimica et biophysica acta Vol. 444; no. 2; pp. 531 - 538
• Main Authors: Burchell, B., Bentley, P., Oesch, F.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 24.09.1976
• Subjects: Animals; Deoxycholic Acid - pharmacology; Detergents - pharmacology; Enzyme Activation; Epoxide Hydrolases - metabolism; Freezing; Glucuronosyltransferase - metabolism; Hexosyltransferases - metabolism; Hydro-Lyases - metabolism; Male; Microsomes, Liver - enzymology; Potassium Chloride - pharmacology; Rats; Sodium Dodecyl Sulfate - pharmacology; Sonication

Epoxide hydratase activity in liver microsomal preparations from adult male rats is latent to a slight extent. Maximal activations with neutral or anionic detergents were 30–60% whilst UDPglucuronyltransferase was maximally activated by 160–830% by the same detergents. Activation of microsomal epoxi...